Effects of CBG - What are the positive and side effects?
Author: Lucie Garabasova
Cannabigerol (CBG) is one of many compounds known as cannabinoids found in cannabis plants. In recent years, scientific interest in CBG has been steadily growing, particularly due to its promising effects. In this article, we will take a closer look at CBG, exploring both its positive effects as well as any potential side effects.
How does CBG work in our body?
Like other cannabinoids, CBG works by affecting the endocannabinoid system in our body. The endocannabinoid system is a complex network of receptors (CB1 and CB2 receptors), chemicals known as endocannabinoids, and enzymes.
Endocannabinoids are compounds produced by our body. They bind to CB1 and CB2 receptors, and their role is to help regulate many of our physiological functions and maintain a state of internal balance.
CBG primarily binds to CB2 receptors.
Although CBG is one of the first cannabinoids in the cannabis plant (even referred to as the "parent" of cannabinoids), research on its effects doesn't go as far back as studies on CBD. As a result, most studies have been conducted on animals, and we also rely on our own references to CBG.
Anti-inflammatory effects
A study on CBG for inflammatory bowel disease (IBD) yielded interesting results. Researchers found that CBG reduced inflammatory markers in animals with induced IBD (idiopathic intestinal inflammation) and alleviated colitis. Based on these findings, the authors of the study suggest that CBG should be further tested on human subjects as a treatment for IBD.
Neuroprotective effect
In addition to its anti-inflammatory properties, CBG may also act as an antioxidant, protecting the nervous system from damage.
Another animal study on the neuroprotective effects of CBG revealed some interesting findings. It was discovered that CBG could help improve motor deficits and preserve neurons in neurodegenerative diseases like Huntington's disease.
CBG as an appetite stimulant
Researchers discovered this effect in a 2016 study on CBG. They administered either CBG or a placebo and observed eating habits. Those who took CBG increased their number of meals and doubled their overall food intake.
CBG could be a promising solution for conditions that cause eating disorders.
CBG for bladder issues
A 2015 study on cannabinoids for bladder dysfunction found that CBG can reduce acetylcholine-induced bladder contractions. Among all the cannabinoids tested, CBG was one of the most effective, along with A9-tetrahydrocannabivarin (THCV). It was also shown that CBG reduces these contractions in human subjects.
Effects on glaucoma
CBG improves fluid drainage from the eye and reduces intraocular pressure. Additionally, the cannabinoid acts as a vasodilator in the eye, improving blood circulation. This increased and oxygen-rich blood flow to the eye can be useful in treating other eye conditions.
Helps with depression treatment
CBG blocks serotonin receptors, suggesting an important role in the treatment of depression.
Does CBG have side effects?
CBG has very few reported side effects and is said to counteract the psychoactive effects of THC.
The potential side effects of CBG may include
- Muscle weakness
- Nausea and vomiting
- Dizziness
Overall, the side effects of CBG are comparable to those of CBD.
Sources
[Way of Leaf](https://wayofleaf.com/education/cbg-what-is-cbg-how-does-it-work-and-what-is-it-used-for)