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    PEA: The Promising Alternative to CBD for Pain and Inflammation Relief

    Author: Lucie Garabášová

    Looking for an alternative to CBD? Try PEA! PEA stands for palmitic acid monoethanolamide, which, according to available studies, has promising therapeutic effects, especially analgesic and anti-inflammatory properties. Let's take a look at how it specifically works and where we can find PEA and its substances.

    What is PEA?

    Palmitic acid monoethanolamide, abbreviated PEA, is a naturally occurring endogenous compound in the body. It is formed by a reaction between palmitic acid and monoethanolamine. Palmitic acid is a fatty acid found in many natural fats, such as palm nut oil or coconut oil. PEA was first isolated and identified in 1957 in the Netherlands by Dutch scientist Dr. J.J. Hesselink, who named it palmitoylethanolamide.

    Monoethanolamine (MEA) is an organic compound that contains an amine and a hydroxyl group. The reaction between palmitic acid and monoethanolamine produces an ester used in cosmetic and pharmaceutical products.

    PEA is mainly used for its properties that positively affect pain and inflammation. You can find it in dietary supplements or cosmetics like creams.

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    How Does PEA Work?

    PEA is primarily associated with anti-inflammatory and analgesic effects through interaction with the endocannabinoid system, similar to CBD products.

    Mechanisms of Action of PEA:

    • Interaction with the Endocannabinoid System: PEA interacts with the endocannabinoid system, which regulates inflammation, pain, and other physiological processes.
    • Stabilization of Cell Membranes: PEA affects membrane stability and integrity, influencing signaling pathways and inflammatory processes.
    • Inhibition of Mast Cell Activation: Mast cells are closely associated with allergic and inflammatory reactions. PEA inhibits the activation of these cells.
    • Modulation of the Immune Response: PEA regulates the production of inflammatory mediators, influencing the immune response.
    • Interaction with Peroxisomal Receptors: PEA interacts with peroxisomal receptors (PPARs), nuclear receptors that regulate gene expression and play a role in inflammation.

    Studies on PEA

    Neuropathy and Pain: A study on PEA and neuropathy showed that PEA treatment significantly reduced mean pain intensity without adverse effects. The effect was independent of the pathological condition associated with the pain.

    Inflammatory Diseases and Analgesic Effects: Research confirms that PEA improves experimental colitis in animals, mediated by CB2, GPR55, and PPARα receptors, and modulated by TRPV1 channels.

    Neurodegenerative Disorders: Studies have identified PEA as a potential therapeutic agent in neurodegeneration and neuroinflammation, promoting beneficial effects through modulation of synaptic transmission.

    Nervous System Protection: PEA treatment reduces the number of infiltrating astrocytes during Aβ challenge, providing significant neuroprotection.

    Does PEA Have Any Side Effects?

    While several studies have examined PEA, there is not yet enough data to definitively determine its side effects. Generally, most people tolerate PEA well, with mild and rare side effects like nausea, headache, or indigestion. However, individual reactions may vary, so it is best to consult a doctor before starting any new supplement or treatment, including PEA.

    How Can PEA Be Used and Where to Find It?

    PEA can be found in dietary supplements. Specifically, the Endostar line offers products like Endostar Fit and Endostar Relax, combining natural ingredients with PEA as a main active ingredient.

    Endostar FIT: Endostar Fit capsules contain PEA, edestin, sea buckthorn extract, turmeric, and Camu Camu. They are recommended for body regeneration, recovery periods, and during times of increased stress. The dosage is 1 capsule three times a day with meals.

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    Endostar Relax: Endostar Relax is suitable for those feeling irritable and stressed, aiming to calm the mind, improve sleep quality, and reduce anxiety. The product contains coriander and clove extract, PEA, and Oleoylethanolamide (OEA). The dosage is 1 capsule three times a day.

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    Conclusion

    PEA offers a promising alternative to CBD with its analgesic and anti-inflammatory properties. With ongoing research and its inclusion in dietary supplements, PEA is becoming an increasingly popular option for those seeking natural relief from pain and inflammation.